Analysis performed on 2024-07-10 11:40:49
| Initial | Filtered Out | Final | Blast | |
|---|---|---|---|---|
| Bacteria | 87463 | 1738 | 85725 | 25825 |
| Archaea | 6380 | 153 | 6227 | 1427 |
| Vertebrata | 2094 | 657 | 1437 | 417 |
| Mammals | 1049 | 173 | 876 | 128 |
| Protein Length | Pathogenic Variants | Benign/Unknown Variants |
|---|---|---|
| 589 | 11 | 471 |
| Domains | |
|---|---|
| Current Study | No Domains Found |
| Guo et al (2010) | No Domains Listed |
| Ancient Domains | Modern Domains | All | Ratio | |
|---|---|---|---|---|
| Number of Residues | 589 | 0 | 589 | Undefined |
| Number of Variants | 482 | 0 | 482 | Undefined |
| Number of Pathogenic Variants | 11 | 0 | 11 | Undefined |
| Number of Benign/Unknown Variants | 471 | 0 | 471 | Undefined |
| Fisher exact test | Undefined |
The Fisher exact test was calculated using a contingency table with the number of pathogenic and benign/unknown variants in ancient and modern domains. The bottom left values.
| Ancient Domains | Modern Domains | All | Ratio | |
|---|---|---|---|---|
| Number of Residues | 589 | 0 | 589 | Undefined |
| Number of Variants | 482 | 0 | 482 | Undefined |
| Number of Pathogenic Variants | 11 | 0 | 11 | Undefined |
| Number of Benign/Unknown Variants | 471 | 0 | 471 | Undefined |
| Fisher exact test | Undefined |
The Fisher exact test was calculated using a contingency table with the number of pathogenic and benign/unknown variants in ancient and modern domains. The bottom left values.
| # of sites Ancient | # sites Modern | Mean Ancient (SD) | Mean Modern (SD) | Median Ancient | Median Modern | Mann-Whitney U | p-value | |
|---|---|---|---|---|---|---|---|---|
| Current Study | 589 | 0 | 0.90 (0.01) | nan (nan) | 9.626e-01 | NaN | Undefined | Undefined |
| Guo et al (2010) | 589 | 0 | 0.90 (0.01) | nan (nan) | 9.626e-01 | NaN | Undefined | Undefined |
The Mann-Whitney U test was calculated using the conservation scores of the amino acids in ancient and modern domains. The p-value is for the null hypothesis that the conservation scores in ancient domains are greater than in modern domains.